The actresses who play Nid and Noi are real sisters.
The director claimed that he made the movie because he wanted to work with Chris Doyle (the cinematographer), Asano (Kenji), and Miike.
The Thai title means, literally, "Love Story, a Little, a Lot" with a play of words on "Noi" and "Nid" which means "few" and "small" respectively. The two words are also the names of the sisters in the movie so the title can also means "Love Story of Noi and Nid, a Lot" (mahasan = infinitely a lot, a great amount). Another interpretation can be "A small/little Love Story that is a lot".
The title isn't displayed until over 30 minutes into the film.
Yukio Mishima, the author of "The Last Lizard", the book featured in the film, committed Harakiri (suicide by stabbing yourself in the stomach with a short knife). This is perhaps one of the reasons why Kenji likes the author.