According to Rob Lowe, during the filming of the final confrontation with Kurt Barlow, Rutger Hauer went off script, but remained in-character, and launched into a bizarre non-sequitur soliloquy about wanting to be a cowboy. Director Mikael Salomon was not impressed, quickly yelled "Cut!" and asked Hauer what he was doing. After a very tense negotiation, Hauer agreed to stick to the original script, but had not bothered to learn the original two-page speech he gave, so had to read it off cue cards.
Rutger Hauer previously played the leader of a coven of vampires in the film version of Buffy the Vampire Slayer, which also featured Donald Sutherland in a supporting role.
At the time of production, James Cromwell (Father Donald Callahan) was married to Julie Cobb, who played Bonnie Sawyer in the previous adaptation Salem's Lot (1979).
Approximately three hundred extras were used during the production.
The name of the town in the novel is Jerusalem's Lot and both it and Sidewinder, from "The Shining", are mentioned in another Stephen King novel "Doctor Sleep".