Until this film, Meat Loaf had not sang in a movie since The Rocky Horror Picture Show (1975) because he wanted to be accepted in the industry as a serious actor. He even thought that his appearance in "The Pick of Destiny" would "ruin" him, but he took the role of JB's father anyway.
Jack Black said that he vowed never to write a script again because the box office failure of this film made him lose his confidence.
The guitar played by Satan in the "Beelzeboss" sequence is a custom Dean guitar designed by Dimebag Darrell Abbott of Pantera, presented to him when sales of their "Far Beyond Driven" album reached 100,000 copies sold.
One of two films in which Troy Gentile plays the childhood version of Jack Black's character. The first came earlier in 2006, when he portrayed the young version of Nacho in the Paramount Pictures family comedy Nacho Libre.
Upon entering the music store in search of the 'Pick Of Destiny', KG (Kyle Gass) is seen wearing a Trainwreck t-shirt. Trainwreck is a group in which Gass is a vocalist and guitarist (under the pseudonym Klip Calhoun). He also produced the group's 2004 live album.