The film was shot entirely in the United States, with an American cast and crew. Nobody in the Canadian film industry wanted to be involved with it.
Since the film's release, Misha Collins has said that he regrets participating in it. He said that he was unaware of the infamy and strong emotions in Canada surrounding the crimes. After a telephone conversation with a victim who managed to escape, he now routinely tells people not to watch the film, especially when it comes up at Supernatural (2005) conventions. Occasionally, fans ask him to sign their DVDs of the film.
Laura Prepon had to dye her hair blond for this film. As a result, her character in That '70s Show (1998) had blonde hair for the show's last two seasons.
Except for Tammy Homolka, the names of the victims were changed because of their ages. The circumstances of their deaths remain the same.
In real life, Paul Bernardo and Karla Homolka legally changed their last name to Teale before they were arrested, after Kevin Bacon's character in Criminal Law (1988).