This video game takes place in the Normal Timeline of the Pokémon multiverse, together with Pokémon FireRed Version (2004), Pokémon LeafGreen Version (2004), Pokémon Platinum Version (2008), Pokémon HeartGold Version (2009), Pokémon SoulSilver Version (2009), Pokémon Black Version (2010), Pokémon White Version (2010), Pokémon Black Version 2 (2012) and Pokémon White Version 2 (2012).
The Team Aqua and the Team Magma are the main antagonists of this video game.
Wallace, one of the main gym leaders becomes a main Pokémon champion.
Juan becomes a main gym leader from Sootopolis City.
Steven becomes to spend more time looking for rare rocks and stones.