In the scene where the flies are in the lunchbox, and being placed in the car, the license plate reads "FMTT - Moon" or "Fly Me To The Moon", the movie's name.
As the lunar module lands on the moon, Edwin Eugene "Buzz" Aldrin, Jr. is shown on the left side, which is the Command position, with Neil Armstrong on the right side. This is the reverse of how they were in reality. Furthermore, Armstrong is shown clapping Aldrin on the arm and calling him "Commander". In the end credits, all three Apollo 11 astronauts are named Commander (a military rank none of the astronauts held, Michael Collins and Aldrin were Air Force Colonels). The upshot is that, in this fictionalized version of Apollo 11, Aldrin commanded the mission and landed the craft, while Neil Armstrong still makes the historic first walk on the moon. With the roles reversed, "Buzz" Aldrin had campaigned internally within N.A.S.A. for this to be how the mission took place, that with Armstrong being in command, it would be Aldrin to make the first exit through the door. This movie's reorganization of the positions and ranks may have been made at Aldrin's suggestion, since he was involved in this movie.
Fourth movie where Christopher Lloyd (first three being the Back to the Future trilogy) is involved with a McFly family. Instead of being friends with a McFly, this time he IS a McFly playing the character "Amos McFly".
Final theatrical movie of Charles Rocket (Mission Control 1961). He died on October 7, 2005, and this movie was dedicated to his memory.
This was the last movie reviewed by Richard Roeper during his tenure as a critic on Siskel & Ebert (1986) (which had been renamed "Ebert & Roeper at the Movies" following Gene Siskel's death). Roeper and his co-host, Michael Phillips (who was substituting for Roger Ebert) gave this movie a negative review. (Philips returned to co-host the show with critic A.O. Scott, before it was cancelled in 2010.