On the 'Grounded' podcast with cousin Louis Theroux, Justin Theroux acknowledges that after the film was acquired by Harvey Weinstein, he as the director lost control of the edit. Athough there were performances Theroux was proud of, he does not feel ownership of the theatrical release.
Mia Farrow and Bob Balaban were originally set to play the roles of Dianne Wiest and Tom Wilkinson's.
During his "confessional" moment when Henry lists several facts about himself, he mentions his towel that he can't get rid of because he "doesn't want to hurt its feelings."
Later when Henry opens his bag to look for the stone, the stone is shown lying on top of the towel.
On the "Fly On The Wall" podcast, Justin Theroux, one of the writers on Tropic Thunder, states he based the character of Les Grossman (Tom Cruise) on his experiences with Harvey Weinstein. The Weinstein Company purchased the rights to Dedication after Theroux directed it and they controlled the editing.