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Dr. Sinister (1964)

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Dr. Sinister

The Flintstones

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In this episode, a spoof of the James Bond film franchise, the title villain makes his lair inside a dormant volcano. The James Bond film You Only Live Twice (1967), released three years later, also features a villain who makes his lair inside a dormant volcano.
Madame Yes is an obvious play on the character from the first James Bond film, Dr. No (1962).
The highest rated Flintstones episode on IMDb.

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