Bradley Cooper put himself on tape to audition for a role as Robert De Niro's son, with his own mother playing DeNiro's part. He lost out to Sam Rockwell.
The second movie in which Lily Mo Sheen plays her real-life mother Kate Beckinsale as a young girl, the first being Underworld: Evolution (2006).
Remake of "Everybody's Fine" (1990), an Italian movie starring Marcello Mastroianni in the DeNiro role.
During the film, Frank (Robert De Niro), who made his livelihood in telephone wire, uses land-line telephones (payphones, et cetera), and his kids all use mobile (wireless) telephones.
Sir Paul McCartney wrote the ballad "(I Want To) Come Home" after seeing an advance screening. It was later nominated for a Golden Globe for Best Song.