Originally Wes Craven had the idea of Brenda, from the first film, enlisting in the National Guard to overcome her fears, only to be sent back to the same desert with the mutants. She was to be the only one who knew where the mutants hideout was located. This idea was cut since the actress was involved with Lost (2004) at the time.
The mine shafts were created by the same team who are responsible for the caves in Brit horror The Descent (2005).
The cast members who play National Guard trainees had to learn rope mountain climbing for their roles.
Wes Craven, the writer and director of the original 1977 version, wrote the screenplay for the sequel to the 2006 remake of The Hills Have Eyes (2006) along with his son, filmmaker Jonathan Craven.
The feces in the Porta Potty was made out of stewed prunes.