Near the beginning of the movie, when the hotel guests are first seen arriving, Dracula (Adam Sandler) mentions that the hotel has been in operation since 1898. It is also shown that Mavis' mother was killed by a mob in approximately 1895 (based on a family portrait showing Mavis at around one-year-old with both of her parents). Bram Stoker's Dracula was written in 1896 and released in 1897. So this movie actually uses a chronological order following the original Dracula story, as if it were a telling of the original Stoker novel.
Notice Frank's light-blue skin, while some interpretations recolor Frankenstein's Monster as green, the original black-and-white movie's makeup was indeed pale blue, to give the impression in monochrome of pale and injured tissue.
In the movie commentary, it is mentioned the town at the end with the fair is loosely based on a real town known as Sighisoara, Romania. Sighisoara is also known as the birthplace of Vlad the Impaler, the real Count Dracula and is the only inhabited citadel in Europe, outside Corsica (where all the citadels are inhabited).
Typically, animated films have actors and actresses record their dialogue separately, but Genndy Tartakovsky wanted Adam Sandler, Kevin James, David Spade, and Steve Buscemi together to record like it was live-action.
(At around ten minutes) Among the decorations on the wall of Mavis' room is a poster that very clearly resembles her real-life voice actress, Selena Gomez.
Jackie Sandler, Sadie Sandler: Dracula's wife and the infant version of Mavis are voiced by Adam Sandler's wife and daughter.