Anna Faris chose to appear nude in one scene instead of using a body double. The reactions from the other actresses are genuine when she walks out nude. "It was my first nude scene and it wasn't supposed to be me," she explained in an interview. "I had a body double and we had some complicating factors with her. It was sort of a last-minute thing, where I said, 'I'll just go ahead and do this.'" She also said she felt like it's what her character Shelley would do, so she should do it too. She even turned her head during the shot so people would see it was her and not a double. Faris said that she broke her "no nudity" clause to do it but, she thought the whole thing was uncomfortable. "This crew that I'd been working with, that knows me when I put on my producer hat, suddenly sees me naked. It was really humiliating. I definitely think I lost some street cred as a producer with the whole crew, being naked in front of them. You have to wear little pasties. You can't wear a full bra and it's not even like covering up. It was a little embarrassing but I'm used to that now. Keenan (Wayans) told me early on that, "There's no vanity in comedy. You can't be vain and funny at the same time". So I've really tried to embrace that idea, that you just have to be fearless."
The movie came about when Anna Faris wondered what happens to the Playboy Bunnies if they leave the mansion.
At the last minute, the director told Anna Faris (Shelley) to do a funny voice as she was introduced to the sorority girls and the iconic "Monster Voice" is what came out of her mouth. The shock on the faces of the other actresses is very real.
Anna Faris later did a cover for Playboy, clothed, because her publicist wouldn't allow her to do it nude.
Anna Faris got lip injections for her role, as she thought her character would have them. She also wore an "industrial-strength" push up bra to mimic the appearance of breast implants, which she did not have at the time.