When Quinton Aaron auditioned for the film, he was working as a security guard between acting gigs. After his audition, he left a card with his contact information and offered to work as a security guard on the set in case he wasn't selected to play Michael Oher.
Collins Tuohy, an A student, rearranged her schedules, and dropped out of several advanced placement classes, to share more classes with Michael Oher and help him graduate.
Julia Roberts was offered the role of Leigh Anne Tuohy before Sandra Bullock, who turned it down three times because of her concerns about playing the part of a devout Christian. During the first couple of weeks of shooting, Bullock thought her acting was so bad she considered dropping out. John Lee Hancock had worked so hard on the project she didn't want to ruin it. However, she didn't quit and ended up winning the Best Leading Actress Oscar for her performance.
When the Tuohys are riding home from S.J. Tuohy's school play, Sean Tuohy says the "quesadilla saved our ass". According to the book, Taco Bell sales were down at one time and Sean's stores were in some financial trouble. Then, Taco Bell introduced the quesadilla and sales increased and Sean's stores prospered.
Sandra Bullock took a pay cut to make the film and agreed to a percentage of the film's profits, which turned out to be considerable.