Chris-Alice's name is a reference to chrysalis, which is a term in the cycle of butterflies and other insects.This is a reference to the personality of chris-alice which is immature
Trevor Wall, director of the series, wanted to make an animated adaptation of the literary work The Metamorphosis by Franz Kafka; Although Nickelodeon and Mike Young Productions executives made certain changes to the story by turning the main character into a girl who instead of becoming a bug, was raised by them.
Although it was decided not to completely adapt "The Metamorphosis" by Franz Kafka, In episode 18 there is a reference to this work because the "Headless Cockroach Man" is a tribute to the invertebrate in which the protagonist of the book becomes.
each episode mixes plots with scientific facts and fantasy however at the end of each episode Creepie breaks the fourth wall to explain to the audience true scientific issues about the insect, invertebrate or fact that were covered in the chapter.
The sports mascot of the Middlington Middle School is a bullfrog, a predator of many insects, this refers to how Creepie is treated by the Middlington students.