Tyson Ritter, lead vocalist and bassist for the band All-American Rejects, guest stars in the cold open as himself.
Another episode where one patient turns into two, although the circumstances are unique, as House and his team work to save the lives of a mother and her baby.
As House tries to book a plane he says that he doesn't want a layover, listing several cities as examples, the last of which is London, Ontario. Series creator David Shore is from London, Ontario.
According to the patient in her hospital room, she uses a Canon digital camera then glances at the back to see if she got her shot. However, while we hear the sound effect of an auto film advance after she views each exposure, digital cameras do not have developed film. While some may say that the extra part on the base of the camera body is a film advance unit, it is an additional battery unit.