The first Transformers series since Transformers: Armada (2002) to not use CGI to represent the robotic characters.
John Moschitta Jr., the original voice actor of the fast-talking Autobot Blurr returns to reprise his role again. Although this time Blurr actually speaks coherently. In The Transformers (1984), the original Blurr often simply repeated his lines.
This is the first, and so far only, Transformers continuity family in which the rank of Prime isn't the highest in the Autobot Army.
Art director and character designer Derrick Wyatt is one of the few official Hasbro employees who had already been Transformers fans even before being employed by the company.
Since a number of the people who worked on it had been fans of the franchise already, Transformers: Animated is famous for including many, many references and gags that only more hard-core Transformers fans can get. Besides the cartoon, the comics, the "Allspark Almanac" books, and even the websites dedicated to it are practically full of obvious and obscure references, citing not only Transformers trivia, but also details of other sci-fi franchises, and in some cases, mentioning famous Internet-going fans and unofficial fan terms too.