The fact that Dewey never mentioned his sister Tatum or her death was an oft-criticized aspect of the prior sequels, making it seem like she had been forgotten. Here, we see that he still keeps her ashes on the mantle.
Neve Campbell was initially hesitant to return to the franchise, especially in a new Scream film that didn't feature Wes Craven as director, who would be unable to give Campbell and the new directors his blessing due to his death. What changed her mind was a letter sent to her by Matt Bettinelli-Olpin and Tyler Gillett, where they wrote about how much Wes Craven and his films meant to them as filmmakers.
Like all previous four Scream films, Roger L. Jackson is actually on the phone with the characters as Ghostface.
David Arquette, who is a certified Bob Ross painting instructor, taught several of the cast members how to paint like the legendary artist during filming breaks.
In the original film, Sidney uses an online 911 emergency system to call for help. This scene was meant to show her typing her address, 34 Elm Street, but it was cut for time. It isn't until this film that an Elm Street in Woodsboro is seen, made canon, and confirmed to be the street Sidney grew up on. Elm Street is, of course, a reference to the Wes Craven classic, A Nightmare on Elm Street.