George A. Romero had plans to make two more sequels which he would film back-to-back, starting with "Road of the Dead". Unfortunately, illness and ultimately his death in 2017 prevented any of this happening.
This was the least successful film in George A. Romero's Dead films series. On a budget of $4 million, it only made $100,000. Even the DVD sales were below expectations.
This film marks the first time that a character from a previous Living Dead film returns to star in a sequel, with Alan Van Sprang as Sarge "Nicotine" Crockett having been seen in Diary of the Dead (2007), and also playing Brubaker in Land of the Dead (2005). The only two other times this has come close to happening was Tom Savini reprising his role of Blades from Dawn of the Dead (1978) as a cameo in "Land of the Dead" in zombie form, and Joseph Pilato playing an unnamed police captain in "Dawn of the Dead" returning to play Captain Rhodes in Day of the Dead (1985).
The first horror film to be nominated for the Golden Lion at the Venice Film Festival since 1932's Dr. Jekyll and Mr. Hyde.