The front cover for each version of the game is different. The Xbox 360 version has Homer cheering, the Wii version has Homer being attacked by an alien, the PS3 version has Homer kneeing Itchy, the PS2 version has Homer being bitten by NeverQuest Ralph, the PSP version has Homer being attacked by Krusty the Clown toys and the Nintendo DS version has Homer being attacked by chocolate bunnies.
In the PS2 version, you can only walk around The Simpsons house. But in the PS3 version, you can walk around Springfield.
This game features cel-shaded graphics, in contrast with the solid 3D rendering used in the previous three 'The Simpsons' games released.
Electronic Arts planned to develop a sequel to the game, entitled The Simpsons Game 2, but was cancelled in 2011 because the studio decided to make room for other projects.
When you hear the cliches it is spoken by Comic Book Guy.