When Merritt Wever won a 2013 Emmy for Outstanding Supporting Actress in a Comedy Series for playing Zoey Barkow in Nurse Jackie (2009), her entire acceptance speech was: "Oh, my God, thank you so...thanks so much! Um...thank you so much! Um...I gotta go. Bye."
Nurse Jackie is the sixth television series to feature both Edie Falco and Paul Schulze; the other five being Homicide: Life on the Street (1993), Oz (1997), the The Sopranos (1999), Law & Order (1990), and New York Undercover (1994). New York Undercover and Law & Order are the only two of the six that the two were not featured in the same episode.
The East 25th Street entrance of the William and Anita Newman Vertical Campus of Baruch College in the Gramercy section of Manhattan served as the entrance façade of All Saints Hospital at which Nurse Jackie and her colleagues work during the first three seasons. In the fourth season, the hospital's entrance façade was changed to Bellevue Hospital at East 27th Street and First Avenue.
Despite the change of show-runners after season 4, Liz Flahive remained the only writer to have worked on the show every season.
Paul Schulze (Eddie Walzer) also starred alongside Edie Falco in The Sopranos (1999) from 1999-2006.