Composer Yôko Kanno, who scored the music for Cowboy Bebop (1998), returns to score the music for this series.
Kôichi Yamadera was enthusiastic about reprising his role as Spike Siegel: "Cowboy Bebop is an important work for me. I have long anticipated a live-action version. I can feel the strong respect it has toward the anime. I hope that viewers will see the atmosphere of the Spike character that I previously portrayed in John Cho's performance, who is skillfully taking on the role in this version. There are also many settings and developments that can only be pulled off in a live-action series. I hope that both people who love Cowboy Bebop and those who are new to the title can enjoy this new series!".
The Japanese dub of the show has the original voice actors of Cowboy Bebop (1998) reprising their original roles: notable examples includes Kôichi Yamadera (Spike Spiegel), Megumi Hayashibara (Faye Valentine), Norio Wakamoto (Vicious) and Gara Takashima (Julia). The exception is Jet Black, who is played by Taiten Kusunoki; Kusunoki replaces Black's original voice actor Unshô Ishizuka, who had passed away in 2018. Other replacements are Masako Isobe, who replaces Kazuaki Ito as Spike's former mentor Mao, and Romi Park, who replaces Nobuyuki Hiyama as one of Vicious' twin enforcers Shin.
Mason Alexander Park (Gren) has a tattoo with the phrase, "Whatever happens, happens." It is one of the most popular quotes in Cowboy Bebop (1998).
Spike Spiegel's appearance is inspired by Japanese-Korean actor Yûsaku Matsuda's portrayal of Shunsaku Kudo in The Detective Story (1979), which is mentioned by director Shinichiro Watanabe in the Cowboy Bebop: The Movie (2001) DVD extra.