Director Juan José Campanella was not happy with the English translation of the title. The original title was intentionally ambiguous, since the Spanish word "sus" could mean "their", but also "his" or "her".
Guillermo Francella (who is a very well known comedic actor in Argentina) had to shave a mustache he had worn for more than 20 years, at the request of director Juan José Campanella.
Pablo Rago, who plays Ricardo Morales, is the only Argentinian actor to play in both Argentinian Oscar winner movies: The Official Story (1985) and El secreto de sus ojos.
When Pablo Sandoval explains the "passions" of the main characters, in the pub scene, he compares Irene with Susanita in her bride-to-be mania. Susanita is a character in the famous Argentinian comic-strip Mafalda, by Quino. Susanita is a blonde elementary school girl who is known for always talking about her future handsome husband and her future beautiful wedding, when she is not gossiping about the neighbor's marriages.
In 2010 it became the second Argentine film to win an Academy Award for Best Foreign Language Film. The previous one was The Official Story (1985).