Destination: Sao Paulo is not just a miniseries which depicts the everyday life of some groups of foreigners in the world's second largest city. Over six episodes in draws an intimate portrait of the metamorphoses immigrants have to undergo to overcome the barriers they encounter in trying to settle in this complex city. Destination: Sao Paulo has as its principal focus love in all its forms and how it is experienced by these new citizens - eternal, fleeting, maternal, fraternal, conventional or controversial. It is with love as its starting point that it searches for whatever is universal in human relationships.
—HBO Latin America