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THIS SUMMARY CONTAINS SPOILERS: Lose with English is based around a bizarre inventor of fitness devices by the name of English Jones, which leads him to TV fame and fortune followed quickly by debt and disaster as English's inventions fail, resulting in injuries and poisoning in various catastrophic ways. Failure brings out the usual suspects including debt collectors, the intelligence services and even the Italian mafia as English goes into hiding. The plot thickens as the FBI and Interpol get involved and the mafia attempt to terminate the contract. English meanwhile is holed out incognito, working as a pizza delivery boy in a Pizza takeaway, keeping low and tinkering with his next invention to help rebuild his fortune. The mafia find English and give chase. English cycles off and gets away, resulting in one of the mafia hit men winding up in hospital, but the net is closing in. Under extreme pressure English suddenly invents a new device, which promises to turn his luck around. Everyone is taken in, except the hit men who now want revenge. The climax comes as they enter English's apartment to kill him. English enters followed by his new investors and colleagues, making the hit tricky. The hit men decide to kill everyone and jump out only to be confronted by the FBI and Interpol. English's new invention, a fitness pillow turns out to have been made in China and is full of lead contaminants, resulting in law suits and English's final downfall. Or is it?

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