In Luis Lopez's safe-house, there is a game console which resembles the Xbox 360. Both Grand Theft Auto IV: The Lost and Damned (2009) and Grand Theft Auto IV: The Ballad of Gay Tony (2009) were timed exclusives to the Microsoft console.
If Luis Lopez takes too many shots in one of the bars, he will pass out and wake up in strange places, such as Middle Park or next to the beating heart inside of the Statue of Happiness.
The mission 'Boulevard Baby' marks the first time that sexual intercourse and oral sex is prominently featured in cut scenes in a Grand Theft Auto game.
The game features a club called "Bahama Mama's". "Bahama Mama" was a hit for the disco era group Boney M.
The storyline intersects with the events of both Grand Theft Auto IV (2008) & Grand Theft Auto IV: The Lost and Damned (2009).