Names of some of the St. Edmund Hall dormitory residents are references to actual or fictitious people, with their first and last names switched: "Doe, Grace" and "Nakimura, John" form John Doe (the standard "unidentified person" name) and Grace Nakimura (the female protagonist from the game Gabriel Knight: Sins of the Fathers (1993) by the same writer); "Jensen, Roberta" and "Williams, Jane" form Jane Jensen (the writer of the game) and Roberta Williams (the author of many classic adventure games); "Curry, Claude" and "Verilhon, Tim" form Tim Curry (the actor who voiced Gabriel in "Gabriel Knight 3: Blood of the Sacred, Blood of the Damned") and Claude Verilhon (a.k.a. Rael, the leader of The Raelian Movement, a UFO-centered religious organization).
A sequel was in consideration to be made based on how it was a votable entry on Jane Jensen's Pinkerton Road Kickstarter campaign along with two other games. Upon the the end of the campaign, the Gray Matter sequel didn't win, and the game Moebius: Empire Rising got green lit instead. According to the Gray Matter synopsis, it was going to be about David Styles and Samantha Everett investigating the death of a young student with magical abilities.