Peter Cullen and Frank Welker reprise their roles of Optimus Prime and Megatron in the first weekly The Transformers (1984) since the 1980s.
Originally, Ironhide was to star in the show instead of Bulkhead, but after the writers realized his portrayal would be better suited for Bulkhead, they replaced the character.
The character designers ditched Arcee's classic pink and white color scheme because they thought it would be "too girly" for the cartoon. So they made her blue instead.
One of the few Transformers continuities in which Cliffjumper isn't simply a slightly tweaked and red-colored Bumblebee lookalike, but has his own, very distinct design.
According to the Art of Prime artbook, the Vehicons' car forms were based on the Batmobile.