The series is animated in Adobe Flash.
The show won an Emmy at the 40th Daytime Creative Arts Emmy Awards for Outstanding Directing in an Animated Program in 2013.
Mandel's original idea was for the show to be a live-action sitcom, but new possibilities opened up once they started development for an animated series. The show was pitched to various networks, including Adult Swim.
Curtis Armstrong, who voices the character of Dan, would sometimes get so into character he would leave the recording studio legitimately angry and confuse the directors of his other projects.
The series premiered on January 1, 2011 on The Hub, and ended its first season on July 9, 2011. The second season of Dan Vs. began on November 19, 2011, and continued through June 23, 2012. Dan Vs. was renewed for a third season, which premiered November 17, 2012 and ended on March 9, 2013.