Edgar Wright revealed that since 2010, there has been an email group that the entire cast and crew of the film version has been a part of. The making of the film was considered such a great experience by everyone involved that the email group never disbanded just so everyone could keep in touch. When it was time to cast for this series, rather than go to everyone's agents, Edgar Wright went onto the same email group to ask if anyone would like to reprise their roles. Every single cast member jumped at the chance to play their character again, all of them replying within only three hours.
The director of the movie within the series is called Edgar Wrong, a play on Edgar Wright, the original director of the 2010 film.
In this series, Ramona's occupation changes from an Amazon courier to delivering Netflix DVDs.
Although the majority of the cast from Scott Pilgrim vs. the World (2010) reprise their roles for this series, neither Shôta Saitô or Keita Saitô return to play Kyle and Ken Katayanagi. Instead, this iteration features only one person, Julian Cihi, playing both of the Katayanagi twins.
Griffin Newman voices various minor characters in this show. Newman reportedly was very close to playing Young Neil in Scott Pilgrim vs the World (2010), before ultimately losing the role to Johnny Simmons.