As the original interior sets from Battlestar Galactica (2004) were no longer in existence, many scenes aboard the ship were filmed against green screen and the sets recreated digitally. Artificial lens flare effects were added to many of the interior shots to obscure the CG backgrounds.
When Adama and Coker are summoned to see the Commanding Officer, they are seen riding a speeding horizontal transport pad. This is a reference to the original series transport pad that could be seen rushing Viper pilots to the launch bays during battle.
Tricia Helfer vocally reprises her role of Number Six and recycles both her first line of "Are you alive?" and snapping someone's neck from Battlestar Galactica (2003).
Many of the crew members on the Osiris were played by actors who played recurring characters on Battlestar Galactica. Jill Teed (Commander Ozar) was Sergeant Hadrian, Ty Olsson (Helmsman) was Captain Aaron Kelly, Mike Dopud (Captain Deke Torvald) was Crewman Specialist Gage, and Sebastian Spence (Lt. Jim Kirby) was Lt. Noel 'Narcho' Allison.
Brian Markinson and John Pyper-Ferguson had both been in the previous Battlestar Galactica (2004) prequel Caprica (2009). John Pyper-Ferguson was also in Battlestar Galactica (2004).