Even though the show is set in San Francisco, and some of the pilot was filmed in the city and on Alcatraz itself, the producers of the show opted to film the rest in Vancouver, mainly because of the much more attractive production rebates than California and the city of San Francisco could offer, much to the chagrin of the San Francisco film industry.
Det. Madsen drives a green 1968 Ford Mustang 390 GT 2+2 Fastback, the exact color, make and model of the car from Bullitt (1968) driven by Steve McQueen. Bullitt also takes place in San Francisco.