This video game takes place in the Normal Timeline of the Pokémon multiverse, together with Pokémon FireRed Version (2004), Pokémon LeafGreen Version (2004), Pokémon Emerald Version (2004), Pokémon Platinum Version (2008), Pokémon HeartGold Version (2009), Pokémon SoulSilver Version (2009), Pokémon Black Version (2010), Pokémon Black Version 2 (2012) and Pokémon White Version 2 (2012).
The main characters are Hilbert and Hilda.
Looker appears again on this video game.
The main gym leaders are Cilan, Chili and Cress from Striaton City, Lenora from Nacrene City, Burgh from Castelia City, Elesa from Nimbasa City, Clay from Driftveil City, Skyla from Mistralton City, Brycen from Icirrus City and Iris from Opelucid City.
The main villainous team of this game is the Team Plasma, his main members are Gorm, Bronius, Rood, Zinzolin, Giallo, Ryoku and his leader Ghetsis.