Despite multiple stabbings, most of the characters are able to remain conscious and/or move around.
In the Bodega scene, Ghostface stabs his knife into the Bodega owner's shoulder and punches him over without pulling the knife out of his shoulder. In the shot where the Bodega owner is on the ground, the knife is no longer in his shoulder and his hands are on the ground, showing he did not remove it himself.
The lights in NYC subway cars do not flicker on and off like that with regularity. If they do, it's very brief usually and couldn't be depended on by a killer to secretly move through a subway car.
Ghostface tells Gale that they have never spoken over the phone before, but this would seemingly be impossible for the killers to know and something only Gale would know. Given that the killers had extensively researched the previous murders and Gale had written several books about them (which they mention on the phone call had made her rich), and she had also given television interviews, they could have learned through them that she had never been on the receiving end of the "Ghostface" phone calls.
When Samantha uses the knife on the final suspect, you can clearly see the prop blade retract repeatedly.
Despite taking place one year after the events of Scream (2022), which supposedly was during October, and only days before Halloween, all trees and plants in the city are vibrant green instead of orange, red, or brown. Gail's balcony even has outdoor plants that would not survive a cold October climate.
Anyone who has been on Hudson Street in NYC knows: (1) The street signs do not look like the one(s) in the movie. (2) For the full length of it, there are no alleys intersecting Hudson--all are regular streets, with names, signs, apartments, stores, etc. The closest landmark that would match this is Charles Lane, which is a couple of blocks west, intersecting Washington Street, and even this is not a deserted alley, but rather, the back of a set of private homes, complete with windows, doors, and garages, so no dumpsters there. It is also one of the few remaining streets in NYC that still has cobblestones.
In the bodega, the owner never gets the ring of keys to the locked backdoor of his belt before Ghostface stabs and shoots him. But when the girls run out of the bodega as the police are pulling up outside, Ghostface manages to get the wad of keys, correctly figure out which one unlocks the door and unlocks the door to flee out the back all within seconds.
When Quinn is supposedly being murdered, the Core 4 all receive a picture at the same time as a photo share, in theory from Danny to warn them since it looks shot from the perspective of his window. But he didn't know any of the others outside of Samantha prior to that and wouldn't have had their numbers or known which phones were theirs in a crowded NYC building.
It also couldn't have been sent from a different unit as a taunt from the killer BC Quinn is in the room and Ethan had an Alibi, meaning their dad had to be the Ghostface doing the actual killing then.
When it is suggested that Kirby is the real killer, no one feels compelled to point out that, so far, none of the killings have been done by someone who is 5'0 and 110 pounds.
Despite Ghostface taking a blow to the forehead from a frying pan, none of the suspects at the end of the movie show the resulting bruising/swelling that would have occurred.
Nancy Loomis looks as depicted in Scream 2 on an archive photo on a police board along with the rest of the previous Ghostfaces, but she underwent a major weight loss and a cosmetic surgery by that time specifically to stalk Sidney Prescott unnoticed as Debbie Salt, so she's unlikely to have posed for a photo at that time, and it would make more sense for the police to have a pre-Debbie picture.