Cassi Davis and Tyler Perry are the only cast members from the stage play to reprise their roles in the film.
The film is slightly different from the stage play: In the play Shirley has 5 children, in the film she has 3 children; Byron's girlfriend's name is Rose and his baby momma's name is Karen in the stage play, those names was later changed to Renee and Sabrina in the film; Kimberly's husbands name is Jason in the play, in the film his name is Calvin; Shirley has a brother named Monroe in the play, the character Monroe doesn't exist in the film nor is he mentioned; the doctors name in the play is Dr. Wallace, the name of the doctor in the film is Dr. Evans.
The first film to feature Aunt Bam. She didn't return until "Boo! A Madea Halloween".
Loretta Devine and Teyana Taylor appeared in the netflix film The Trap (2019).
All throughout the film, Shirley (played by Loretta Devine) says "I"m tired". Devine also originated the role of Lorell in the Broadway musical Dreamgirls where she sings the lyric "And I'm tired; Effie, I'm TIRED!" in the song "It's All Over".