While critics loved the show, it sagged in the ratings. This led to its eventual cancellation. Several petitions were created to try and save the show or revive it from cancellation, though none were successful.
Krysten Ritter said about the cancellation of the show, "That was the hardest. I was surprised, but I also loved it so much. I cried. I cried before that. There were days driving home from set crying, knowing it was never going to be as good as this again. Because I had the best day."
The show was originally developed by Fox and was titled "Don't Trust the Bitch in Apartment 23." Fox passed and ABC filmed a pilot with the title "Apartment 23." It was chosen as one of the "Most Exciting New Series" at the Critics' Choice Television Awards. The series title was then changed to a bowdlerized version of its original name.
The episodes were aired out of order on ABC. The correct order is: 1. Pilot; 2. Daddy's Girl; 3. Mean Girls; 4. The Wedding; 5. The Scarlet Neighbor; 6. Whatever It Takes; 7. Making Rent; 8. It's Just Sex; 9. The Leak; 10. The Parent Trap; 11. Shitagi Nashi; 12. Bar Lies; 13. A Weekend in the Hamptons; 14. A Reunion; 15. Love & Monsters; 16. It's a Miracle; 17. Sexy People; 18. Paris; 19. Teddy Trouble; 20. Monday June; 21. Dating Games; 22. The D; 23. The Seven Year Bitch; 24. Using People; 25. Ocupado; 26. Original Bitch.
Michael Landes, who played Krysten Ritter's father on the show, is only nine years older than her in real life.