Olivia Wilde reprises her role as Quorra from Tron: Legacy (2010), as the voice of Quorra for "Isolated".
Bruce Boxleitner is the only actor from the Tron (1982) film in "TRON: Uprising" as the voice of Tron.
The graffiti used by the Renegade and his team in the "Tron Lives" campaign (similar to the "Flynn Lives" viral campaign used to promote a possible sequel to Tron: Legacy (2010)) shares the multi-streaming line design of one of the original Windows OS screensavers.
Beck's hairstyle is based on a proposed look for Tron in the original Tron (1982) that is visible in some behind the scenes photographs but was not used in the film.