This show featured no Decepticons or any other form of villainous Transformers characters. Aimed at a younger audience, the Autobot heroes of this show instead dealt with the local hazards of their town in order to teach valuable lessons about safety to the children watching it.
Peter Cullen reprised his role as the Autobot Commander Optimus Prime, making this the third cartoon series in which he voiced the character, after The Transformers (1984) and Transformers Prime (2010). He also voiced him in all of the live-action films.
With 104 episodes over five years, this is the longest-running Transformers cartoon ever made. The record was previously held by The Transformers (1984) with its 98 episodes over three years.
Although this show took place in the same universe as its counterpart, Transformers Prime (2010), it only made mostly implicit references to it. For instance, the evil organization, in which Dr. Morocco (Tim Curry) is in cahoots, was most likely M.E.C.H., the Decepticons are initially only referred to as "those who would do harm" (the word Decepticon is used in the first season finale, however), and Optimus Prime called Ratchet their medic, instead of referring to him by name.
Doc Greene's character was a reference to Dr. Emmett Brown from the Back to the Future trilogy.