Dr. Henry Hollinsworth (Cannon Miller) and his wife Ruth make it their mission to help people that are affected by spirits and the other-worldly. One day on a job to an asylum, Ruth is taken and killed. Years later, Henry is suspected of this murder. Along with his partner Victoria, Henry must go back to the dreaded Randolph County Asylum where all of this took place many years prior in order to stop the wrongdoings of the maniacal Claudio Casperio from his dealings in the occult.