Jennifer Aniston was originally cast but after the project was delayed, she dropped out and Rachel Weisz was cast. Weisz also dropped out and Drew Barrymore replaced her.
Drew Barrymore, Toni Collette and their children formed a long-lasting friendship during this shoot.
Two of the close-ups in the film were shot using an iPhone 5. Director Catherine Hardwicke felt it allowed for more intimacy than the use of a regular movie camera.
Drew Barrymore (Jess) was actually pregnant with her second child.
Tyson Ritter (Ace) was so inspired by Toni Collette's performance as Milly he wrote "There's A Place," which is also featured in the movie during a scene the two share.