This show was both set and filmed in the city of Ballarat, which was founded as a gold rush-era boomtown in the Central Highlands of Victoria, Australia. The filming locations were popular tourist attractions, and there was a "Doctor Blake Series" section on Ballarat's regional tourism marketing and development website.
In March 2017, the Australian Broadcasting Corporation announced that they were canceling The Doctor Blake Mysteries and the fifth season would be its last. This was despite the fact that it was consistently their highest-rated Australian-made program. Star Craig McLachlan (Dr Lucien Blake) said in an interview with Australian reporters Prue Bentley and Tony Allan that the network never told him the reasoning behind their decision: "The biggest disappointment was trying to find the logic in it. I'm not blowing smoke up the show's derriere when I say that when the numbers are crunched, it is the most popular global drama on Australian television. The decision didn't make sense. When you're on a good thing, stick to it. The current regime at the ABC, they had their reasons [but] I don't understand them and it's never been articulated to me what their thinking is."