CeeLo Green did not reprise his role as the voice of Murray the Mummy due to being arrested. Keegan-Michael Key replaced him in this film, same said for Hotel Transylvania 3: Summer Vacation (2018) and Hotel Transylvania 4: Transformania (2022).
The parents of Jonathan (Andy Samberg) are voiced by real-life husband and wife, Nick Offerman and Megan Mullally.
When director Genndy Tartakovsky immigrated to America from Russia at age seven, some of the first movies he saw on American TV were Mel Brooks' "Young Frankenstein," "Blazing Saddles," "History of the World Part 1" and "The Producers." "Those were my comedic pillars growing up," says the director. "Mel Brooks is one of the foundations of comedy, he's been around forever, he shaped my comic sensibility, and he's still sharp and witty, so I was very nervous to direct him. He's amazing it's not like he needs directing," says Tartakovsky. "But I remember at one point, he wanted to hear how I thought he should do one particular line. What was I gonna tell Mel Brooks? But he wanted me to do it, so I did it, and he liked it, and he did it the way I did it. That was an amazing moment for me I'll never forget that.
In many ancient cultures, notably Greek, people with red hair were believed to become vampires upon death. It is quite fitting therefore, that Johnny and Dennis have red hair. It is unknown, however, if this is an intentional reference.
This film takes place seven years after the first Hotel Transylvania (2012), and Dracula is 539 years old, Mavis is 125, and Jonathan is 28 years old.