Christopher Nolan's cousin Miranda Nolan was considered for the lead role of Jennifer Lee Johansson.
Since 'Cranium Intel' is one of the first feature films where the President of the United States is the villain. The director wanted to make sure that vision was brought across on-screen when designing the helmet for President Whitaker. A cross between the aero helmets used in pro-cycling of the Tour de France but also keeping a simplified design. Middleton's first thought was having a helmet that would be striking to the eye like Darth Vader in 'Star Wars' saga.
Composer Hardley Davidson (Nelly, The Longest Yard Stk, Chamillionaire) replayed the musical notes of Piano Concerto No. 2 - Andante by Amadeus Mozart in his head without use or need to read Mozart's composer sheet.
This marks the first Cranium Intel Cinematic Universe film in which the Department of the Interior, National Park Service, and the Jefferson National Expansion Memorial allowed the production to shoot scenes at the Gateway Arch, which is St. Louis' prominent national landmark.
In the novel, St. Louis transforms from city to the last state of the United States of America. The remaining of the original state of Missouri joins the other 49 states becoming the Circle District of America.