- Irene Adler: My first instinct was to kill you. Quietly. Discreetly. But then, the more I learned about you, the more curious I became. Here, at last, seemed to be a mind that... that rivaled my own, something too complicated and too beautiful to destroy... at least without further analysis.
- Dr. Joan Watson: The muscle in your shoulder is shredded, okay? You need to be treated for the pain.
- Sherlock Holmes: May I remind you I'm a recovering drug addict?
- Dr. Joan Watson: May I remind you there is such a thing as non addictive pain killers?
- Sherlock Holmes: How good can they be if they're not addictive?
- Dr. Joan Watson: Irene is Moriarty. You think she's here to do something terrible. You have a hole in your shoulder. And we have a dead assassin on the third floor of our home.
- Sherlock Holmes: What's the point of living with a former surgeon if she can't stitch the occasional bullet hole?
- Irene Adler: I would never kill you. Not in a million years. You may not be as unique as you thought, darling, but you're still a work of art. I appreciate art. What I can do - what I *will* do is hurt you, worse than I did before. I have reserves of creativity I haven't even begun to tap. So please, for your own good, let me win.
- Sherlock Holmes: Thanks to her, I now have perfect clarity; you've never seen me with perfect clarity.
- [the woman Sherlock Holmes had known as American artist Irene Adler reveals herself to be his arch-nemesis Jamie Moriarty when she shoots one of her agents gone rogue before he kills Holmes in the brownstone]
- Irene Adler: This isn't how or when I wanted to reveal myself to you. But Mr. Proctor forced the issue.
- Sherlock Holmes: [lying on the floor suffering from a gunshot wound] This is a ruse. You... So who was the man I spoke to on the phone who, uh, said he was Moriarty?
- Irene Adler: You talked to one of my lieutenants. He has, over the years, played the role repeatedly and with great conviction. More often than not it was to protect my identity. Other times it was because I suspected a potential client might... struggle... with my gender. As if men have a monopoly on murder.