After growing up in Compton, Venus' younger sister Serena Williams rises to tennis stardom, winning her first Grand Slam title at 17 at the 1999 US Open.
Sisters Serena and Venus Williams battle for tennis dominance as Serena chases Grand Slam glory after Venus wins four majors, pitting sibling against sibling for the sport's top prize.
After her sister's death, Serena overcomes grief and depression to battle emotions and tough competition at the 2007 Australian Open after dropping out of the top 100 rankings.
The isolation of tennis takes a toll on Serena, leading her to improve her game with a new team. After regaining the #1 ranking, they rally around her during a life-threatening health issue, preparing for the 2011 US Open.
After an early Grand Slam exit, Serena Williams hires Patrick Mouratoglou as her new coach. As she pursues a calendar Slam in her thirties, she draws inspiration from friend Roger Federer's journey.
In 2015, Serena Williams' return to Indian Wells tennis tournament revisits an incident from 2001 where she faced boos and jeers, leading to a 14-year boycott. Serena, Venus, and Mary Joe Fernández recount the experience that sparked this.
During the Italian Open, Serena meets Alexis Ohanian, co-founder of Reddit. After engagement, she enters the 2017 Australian Open aiming for her 23rd Grand Slam while harboring a secret.
After giving birth to Olympia, Serena returns to tennis before retiring ahead of the 2022 US Open, marking the end of her career as she begins a new chapter.