Of all the principal characters in this biopic, Marina Oswald was the only person still living at the time of its release. Oddly, the real Marina Oswald later ended up outliving her portrayer (Michelle Trachtenberg), when Trachtenberg tragically passed away at age 39 (from diabetes mellitus) in 2025.
When Michelle Trachtenberg signed on to play Marina Oswald, her script dialogue was mostly in Russian with some English later added. Her Russian-born mother acted as her translator in helping to break down her entire script both phonetically and vernacularly.
Rob Lowe shares the role of John F. Kennedy with his West Wing cast mate, Martin Sheen.
Of the two Kennedy brothers portrayed in the film, John F. Kennedy was played by an actor named Robert (Rob Lowe) and Robert F. Kennedy was played by an actor named John (Jack Noseworthy).
Boris Mcgiver and Casey Siemaszko were both on the TV show White Collar. Boris Mcgiver played FBI section chief Bruce Hawes and Casey Siemaszko played a P.I. that was tailing a suspect the main characters were investigating.