The title of the film is a reference to the line "Game over, man! Game over!" spoken by Bill Paxton's character Private Hudson in Aliens (1986).
Similar to Workaholics (2011), Adam Devine's lower legs are covered by high socks to mask the scarring on his legs from getting ran over by a cement truck as a child, however, you can vaguely see some of the scarring on his upper legs in the scene where he is naked
At one point, Anders Holm's character says, "I wanted a Home Alone style zip line." The Dew'd Crew then continue to reference Kevin McCallister in their "Zip Tie Zip Line" plan later in the scene. Daniel Stern, who plays the boss Mitch in the movie, starred as Marv in Home Alone (1990) and Home Alone 2: Lost in New York (1992).
Adam Devine, Anders Holm and Blake Anderson were the leads of Workaholics (2011), and whilst it isn't explicitly a 'Workaholics' film, it does share a lot of the cast and crew.
Adam Devine and Utkarsh Ambudkar worked together in Pitch Perfect (2012); both were part of the Treblemakers.