The black and white cat graphic shown in portions of the opening credits is Grumpy Cat's real life brother, Pokey.
Grumpy Cat is a female, and her name is Tardar Sauce.
The second Internet meme to be the basis for a movie, after Safety Not Guaranteed, which also starred Aubrey Plaza.
On "Jimmy Kimmel Live!", Aubrey Plaza stated the film did not make any sense to her and jokingly preferred to watch the film intoxicated.
Chrystal, the main character played by Megan Charpentier, is named after Chrystal Bundesen -- the daughter of Grumpy Cat's real-life owners.