- Johnny Silverhand: The time has come for a close encounter of the third kind... A small step for V, but a giant leap for humankind. Who're you bettin' on showin' up? The reptilians or techno-necromancers?
- V (Male Player): The Spanish Inquisition.
- Johnny Silverhand: I admit, I didn't expect that.
- V (Male Player): Guess I meant, I dunno... a happier ending... for everyone involved.
- Johnny Silverhand: Here, for folks like us? Wrong city, wrong people.
- [What is free often proves most costly]
- Skye: You've never backed down from anything in your life, even when you maybe should've. You go through Night City knowing a stray bullet could end you while hailing a cab. But that's never stopped you from taking action, going where you needed to go. And it won't stop you now.
- V (Male Player): But how do I keep up with everything that's changing?
- Skye: You have been keeping up. You've made an impact. Not a single thing in this world isn't in the process of becoming something else. Likewise you. Never look back. If you gotta kill, kill. If you gotta burn it all to the ground, then let it burn.
- Johnny Silverhand: Give yourself time. Ideas'll come. Life'll shake you, roll you, maybe embrace you. The music'll find you.
- V (Male Player): So, Padre. You think Jackie's looking down upon us... from up there?
- Sebastian "Padre" Ibarra: I believe he has met God, stood before Him.
- V (Male Player): That's it?
- Sebastian "Padre" Ibarra: I don't know if God left the meeting happy, but I'm pretty certain Jackie did.
- Johnny Silverhand: [as Panam falls asleep] On behalf of the staff of Independent California Motel, I wish you sweet dreams.
- Panam Palmer: [Panam, V, and Saul are hiding out in a house trailer during a sandstorm] Yeah, this would make for a decent little motel, wouldn't it? Little fireplace, booze... grumpy guy at reception is the one thing missing.
- V (Male Player): Have everything you need, ma'am?
- Panam Palmer: [resting her legs on V's lap] Mm-hm, I couldn't ask for more.
- V (Male Player): Ma'am, I'm sure you'd be cozier with your shoes off.
- Panam Palmer: [chuckles] After a full day in them? I'd fear a health code violation.
- V (Male Player): Nonsense. After a day as full as today, you deserve to kick back.
- Panam Palmer: Oh? And what did you have in mind?
- V (Male Player): Here at the Independent California, customer satisfaction is job one. Your wish is our command.
- Panam Palmer: [after a pause] Careful, you can't know what I'd wish for.
- Johnny Silverhand: He's fucked in the head, the world's fucked in the head, and YOU'RE fucked in the head because MY fucked up head is inside it. Guess if you wanna save the world, that's the first step; get fucked in the head.
- Johnny Silverhand: Test of a person's true value? Death. Facing it, staring it down. You still got a chance to be somebody.
- Saburo Arasaka: I have found that people lie, most often deceiving themselves. Not so the dead... The dead are so very, very loud. And yet, lying is not in their nature. It is so... humbling - to listen to the dead speak.
- Johnny Silverhand: Sabotage a corpo power station, jump a corpo transport, kidnap a corpo suit...
- V (Male Player): This a plug for the word corpo or do you have a point?
- Johnny Silverhand: Know what? You're starting to remind me of me, fifty years back. Minus the charisma... and impressive cock.
- Rogue Amendiares: Johnny, remember the plan?
- Johnny Silverhand: Get the payload on the elevator, arm it, let gravity do its thing. Explosion rocks the foundation, tower crumbles - chaos, screaming, roll credits.
- Dexter 'Dex' DeShawn: Now, as that old Greek dawg says, life's a banquet - so don't go thirsty, but don't get drunk, either.
- Johnny Silverhand: Swap meat for chrome, live a BD fantasy, whatever, but at the end of it all, it's the code you live by that defines who you are.
- Dexter 'Dex' DeShawn: Would you rather live in peace as Mr. Nobody, die ripe, old and smelling slightly of urine? Or go down for all times in a blaze of glory, smelling near like posies, without seeing your thirtieth?
- Goro Takemura: Yorinobu and his puppets grin at the cameras and insist that everything is under control... but the wider the smile, the bigger the lies.
- V (Male Player): You're a dick, you know?
- Johnny Silverhand: And you're a cunt. Maybe we'll fit together after all.
- V (Female Player): Don't like it, Don't listen
- Johnny Silverhand: Oh, yeah, real mature! Not like I can cover my ears and go 'lalalalala' whenever you open your trap.
- Saburo Arasaka: Did you think I wouldn't know it was taken from me?
- Yorinobu Arasaka: Actually, I don't think of you at all. Ever. You see, that's your problem. You think the world revolves around you. Arrogant.
- Saburo Arasaka: Yorinobu...
- Yorinobu Arasaka: Why did you come? To humiliate me? To personally see to it that your son knows his place?
- Saburo Arasaka: "The nail that protrudes from the wall gets hammered..."
- Yorinobu Arasaka: Couldn't think of anything original to say?
- Saburo Arasaka: And do you think it "original" to sell our greatest achievement to Westerners - our future to these... barbarians?
- Yorinobu Arasaka: Our future? Ours? You are mistaken. You've only ever cared about yourself... and your sick schemes!
- Saburo Arasaka: I knew this day would come. That sooner or later, your impudence would cross the line. There is much for which I could forgive you, but for treason? No. I'm just glad your mother didn't live to see this. The heart should break but once.
- Yorinobu Arasaka: [suddenly attacks Saburo] You shall never have to forgive me for anything again!
- [strangles Saburo to death]
- V (Male Player): Doesn't it bother you?
- Ozob: What?
- V (Male Player): The grenade. You know, the one on your face?
- Ozob: Eh, you get used to it. I just gotta be careful not to pull the pin when I wanna pick my nose.
- T-Bug: "The greatest crimes issue from a desire for excess and not from necessity."
- Jackie Welles: Say what now?
- T-Bug: Aristotle. Guess you read me, then?
- Jackie Welles: Yeah, I read you. Not so much your Greek friend, though it was kind of exciting.