We report a case of alcohol use disorder (AUD) in which pellagra became apparent after an administration of niacin-free vitamins (Vit) B. A man in his 50s, while being treated for AUD, was admitted to our hospital because of fractures to his left upper extremities. Upon admission, the patient was fully conscious with normal neurological findings; however, he exhibited discolored skin extending from the neck to shoulders. He received lorazepam and VitB1, B6, and B12 to prevent alcohol withdrawal symptoms and Wernicke's encephalopathy. On the 5th day after the admission, he showed gastrointestinal symptoms such as diarrhea and ileus, and neuropsychiatric symptoms such as disorientation, hyperreflexia, and myoclonus. On the 32nd day, he was diagnosed with suspected pellagra and was subsequently treated with niacin. Several days later, his dermatitis, and gastrointestinal and neuropsychiatric symptoms improved. In this case, pellagra became apparent after the administration of VitB without niacin, and it is considered that the emergence of pellagra after vitB without niacin may be mediated by increases of 5-aminolaevulinic acid and kynurenic acid and inhibition of tryptophan-2,3-dioxygenase. Clinicians should suspect and treat pellagra when a patient with AUD displays one of three pellagra symptoms, such as impaired consciousness, dermatitis, or gastrointestinal symptoms.
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