Centro Nacional de Análisis Genómico (CNAG)

🔥 𝗪𝗵𝗮𝘁 𝗮𝗻 𝗶𝗻𝘀𝗽𝗶𝗿𝗶𝗻𝗴 𝗱𝗮𝘆 𝗮𝘁 𝘁𝗵𝗲 #𝗖𝗡𝗔𝗚𝗦𝘆𝗺𝗽𝗼𝘀𝗶𝘂𝗺! As part of our 15th anniversary, we hosted last Tuesday, December 16, our CNAG Symposium on Genome Research, focused on cancer genomics. 🔝 A high-level event that brought together leading researchers and experts to share the latest advances in genomic oncology, and their impact on understanding and treating cancer. Once again, the symposium was a great opportunity to share cutting-edge research and foster discussion. 🙌 Special thanks to all of the speakers: sabine Tejpar, Anna Pascual Reguant, Andrés Ramírez, PhD, Eduard Batlle, Sara Gutiérrez-Enríquez, Matteo Spagnoletti, PhD, Marjanka Schmidt, Nadia Sedlyarova, Sergi Beltran Agulló, Vincenzo Lupo, CONXI LAZARO, Roberto Piñeiro Cid, Christophe Fleury. And our sponsors for their support: Illumina, Oxford Nanopore Technologies, Bonsai Lab, Roche and Agilent Technologies. 👀 Stay tuned for more genomic events and scientific insights! 📹 In the meantime, you can watch the full CNAG Symposium on our YouTube channel: https://lnkd.in/eyp8NehT #CNAG #CancerGenomics #GenomeResearch #15YearsCNAG #Genomics #PrecisionMedicine #Cancer #Research

🚀 New paper out in Nature Magazine! We are excited to share our latest collaboration: NeuMap! The first comprehensive atlas of neutrophils across 47 biological conditions in human and mice, revealing how this “first line of defense” reorganises to protect, remember, and heal. 𝘊𝘰𝘯𝘵𝘦𝘹𝘵 ▪️ Neutrophils are the most abundant immune cells in the body and the first to respond to infection or tissue damage. ▪️ Until now, we had limited understanding of how they operate across tissues or contribute to host defence, inflammation, cardiovascular disease, and cancer. 𝘖𝘶𝘳 𝘤𝘰𝘯𝘵𝘳𝘪𝘣𝘶𝘵𝘪𝘰𝘯 ▪️ At CNAG, our researchers Holger Heyn, Juan Nieto Sáchica and Emanuele Pitino, with the collaboration of Max R. and Irene Ruano Feo, contributed through spatial transcriptomics analysis. ▪️ We identified where neutrophils reside within tissues, how they position themselves during disease, and how their local environment shapes their identity. 𝘐𝘮𝘱𝘢𝘤𝘵 👉 NeuMap offers a practical resource enabling researchers to pinpoint which neutrophil states are involved in a given condition and to infer their potential roles, paving the way for improved immune-based therapies. 𝘈𝘯 𝘪𝘯𝘵𝘦𝘳𝘯𝘢𝘵𝘪𝘰𝘯𝘢𝘭 𝘦𝘧𝘧𝘰𝘳𝘵 🌍 The study has been led by an international team of scientists from CNIC - Spanish National Center for Cardiovascular Research / Centro Nac. Investigaciones Cardiovasc., Universidad Carlos III de Madrid, Yale University and Westlake University. 📎 https://lnkd.in/d-cguADC #NeuMap #Neutrophils #Immunology #NaturePaper #SpatialTranscriptomics #SingleCell #Genomics #ImmuneSystem #Inflammation #CardiovascularResearch #CancerResearch #CNAG

🏅 Last week, Meritxell Novillo Font successfully defended her #PhD thesis! ➡️ "A Multi-Omics Approach to Unravel the Epigenetic and Topological Mechanisms Underlying Colorectal Tumorigenesis" 🔝 A new step forward in understanding the mechanisms underlying colorectal cancer (CRC) initiation and progression from a genome topology perspective. In this thesis, Meritxell investigated how transcriptional and epigenetic layers are modulated in CRC by studying the effects of recurrent mutations in the Apc, Trp53, Smad4, and Kras genes. The results further suggest that organoid phenotypes may be influenced not only by the cumulative effect of mutations but also by the order in which they are acquired. 🎓 Directors: Marc A. Marti-Renom and María Martí Marimón 👏 Huge congratulations, Meritxell! #ThesisDefense #PhDLife #Genomics #CNAG #CancerResearch #ColorectalCancer #Epigenetics #3DGenomics #ChromatinBiology #Organoids #CRISPR #MultiOmics

🚨 PhD & Postdoc Alert! If you are looking for a PhD in Barcelona or a postdoctoral research position, this is your chance to join us! 🔎 We are seeking curious, motivated PhD students and postdocs ready to engage in cutting-edge research within a collaborative, international environment. Join a community of over 100 professionals from 25 countries working in genomics and computational biology. Successful candidates will receive a fully funded PhD or postdoctoral contract within the Functional Genomics Research Team at CNAG. Explore the available funding opportunities: 👉 PhD Fellowships ▪️ INPhINIT Retaining – “la Caixa” Foundation (deadline: 18 February 2026) https://lnkd.in/esArhc_e 👉 Postdoctoral Fellowships ▪️ Juan de la Cierva 2025 (deadline: 10 December 2025) https://lnkd.in/dtDWWGVJ ▪️ EMBO Postdoctoral Fellowships (deadline: 23 January 2026) https://lnkd.in/gNn3vB5z ✏️ Please submit your application to: Anna Esteve – anna.esteve@cnag.eu Mireya Fernández – mireya.fernandez@cnag.eu #PhDAlert #PostdocAlert #Genomics #ComputationalBiology #ResearchOpportunity #CNAG #Barcelona #AcademicJobs #ScienceCareers #PhD #Postdoc #FundingOpportunity

⭐ 𝐍𝐨𝐮 𝐢𝐦𝐩𝐮𝐥𝐬 𝐚 𝐥𝐚 𝐫𝐞𝐜𝐞𝐫𝐜𝐚 𝐞𝐧 𝐜𝐚̀𝐧𝐜𝐞𝐫 𝐜𝐨𝐥𝐨𝐫𝐞𝐜𝐭𝐚𝐥! La Fundación ”la Caixa” ha concedit gairebé un milió d’euros a un projecte de recerca en càncer de còlon i recte, impulsat pel Dr. Holger Heyn, líder del Grup de Genòmica de Cèl·lula Única al CNAG, sota la coordinació del Dr. Alexandre CALON, de l'Hospital del Mar Research Institute. En el projecte també hi participen investigadors de la Universidad de Oviedo (Dr. Jorge Pisonero) i de la Universidad de Granada (Dr. Daniele Lo Re). 🎯 𝐿’𝑜𝑏𝑗𝑒𝑐𝑡𝑖𝑢 𝑑𝑒 𝑙𝑎 𝑟𝑒𝑐𝑒𝑟𝑐𝑎 𝑒́𝑠 𝑐𝑜𝑛𝑡𝑟𝑖𝑏𝑢𝑖𝑟 𝑎 𝑛𝑜𝑣𝑒𝑠 𝑡𝑒𝑟𝑎̀𝑝𝑖𝑒𝑠 𝑝𝑒𝑟 𝑎𝑙𝑠 𝑝𝑎𝑐𝑖𝑒𝑛𝑡𝑠 Des del CNAG, utilitzarem tecnologia de darrera generació per crear el primer atles espacial i unicel·lular de tumors colorectals abans i després de la quimioteràpia, una eina clau per entendre la interacció tumor-microambient i obrir noves vies terapèutiques. 📎 https://lnkd.in/dhM7mXKX #HealthResearch #FundaciólaCaixa #FundaciónlaCaixa #laCaixaFoundation #CancerResearch #SingleCellGenomics #ColorectalCancer #BiomedicalResearch #TumorAtlas #Innovació #RecercaBiomèdica #CNAG #Genomics

✅ Ayer participamos en la IV Jornada de las Infraestructuras Científicas y Técnicas Singulares (ICTS), unas instalaciones únicas que, en palabras de la Ministra Diana Morant Ripoll: “𝑆𝑜𝑛 𝑢𝑛𝑎 𝑟𝑒𝑑 𝑑𝑒 𝑣𝑎𝑛𝑔𝑢𝑎𝑟𝑑𝑖𝑎 𝑞𝑢𝑒 𝑖𝑚𝑝𝑢𝑙𝑠𝑎 𝑒𝑙 𝑐𝑜𝑛𝑜𝑐𝑖𝑚𝑖𝑒𝑛𝑡𝑜, 𝑙𝑎 𝑖𝑛𝑛𝑜𝑣𝑎𝑐𝑖ó𝑛 𝑦 𝑒𝑙 𝑝𝑟𝑜𝑔𝑟𝑒𝑠𝑜 𝑑𝑒 𝑛𝑢𝑒𝑠𝑡𝑟𝑜 𝑝𝑎í𝑠.” El acto sirvió como marco para presentar el nuevo Mapa de ICTS 2025-2028, que cuenta ya con 28 ICTS y 64 instalaciones en 15 comunidades autónomas. 🧬 Una de las ICTS es OmicsTech, de la que forma parte CNAG y por la que ayer recibíamos una placa conmemorativa que recogió nuestra Coordinadora Estratégica, Monica Bayes. Nuestro objetivo es ofrecer a los investigadores acceso a tecnologías ómicas de vanguardia, para ayudarles a obtener una visión integral de los procesos biológicos. CIEMAT - Ministerio de Ciencia, Innovación y Universidades #ICTS #ICTSNews #FEDER #FondosFeder #FondosEuropeos #EUFunding #OmicsTech #Genomics

📺 𝐒𝐨𝐫𝐭𝐢𝐦 𝐚𝐥 𝐓𝐍 𝐝𝐞 𝐓𝐕𝟑! Si encara no coneixeu el darrer estudi del CNAG i l'IRB Barcelona, ja no teniu excusa! Els nostres investigadors descobreixen com el càncer colorectal esquiva la immunoteràpia, a través d'una doble barrera. Un important pas endavant per entendre com millorar les estratègies terapèutiques i ajudar a més pacients. 🗣️ Entrevistes a Elena Sancho, Holger Heyn i Ana Henriques 🎤 Un reportatge de la Marta Catafal Gálvez (Corporació Catalana de Mitjans Audiovisuals) 📎 https://lnkd.in/dFVkNpBV #CNAG #TV3 #Reportatge #Media #Recerca #Notícies #Genomica #Catalunya #Genomics #IRBBarcelona

🔝 𝗡𝗲𝘄 𝗽𝗮𝗽𝗲𝗿 𝗼𝘂𝘁 𝗶𝗻 𝗡𝗮𝘁𝘂𝗿𝗲 𝗚𝗲𝗻𝗲𝘁𝗶𝗰𝘀! A new study led by CNAG and IRB Barcelona reveals how metastatic colorectal cancer evades the immune system, uncovering a dual barrier that limits immunotherapy. The groundbreaking discovery opens new avenues to new treatment strategies. 1️⃣ 𝐵𝑖𝑡 𝑜𝑓 𝑐𝑜𝑛𝑡𝑒𝑥𝑡 🌍 Colorectal cancer is the second leading cause of cancer death worldwide 💉 Immunotherapies work in many cancers, but most metastatic colorectal cancers do not respond ⚠️ Tumours with high levels of TGF-β protein are linked to poor prognosis 2️⃣ 𝑊ℎ𝑎𝑡 𝑤𝑒 𝑝𝑒𝑟𝑓𝑜𝑟𝑚𝑒𝑑 🔬 The research combined mouse metastasis models with patient tumour analyses 🔬 At CNAG, the Single Cell Genomics Group sequenced individual tumour cells and performed bioinformatics analyses to characterise the main players affected by TGF-β 3️⃣ 𝑇ℎ𝑒 𝑑𝑖𝑠𝑐𝑜𝑣𝑒𝑟𝑦 TGF-β builds a dual barrier that blocks immune cells from attacking the tumour: • It prevents enough T lymphocytes from reaching the tumour • It triggers macrophages to produce osteopontin, which slows the multiplication of the few T cells that infiltrate the metastasis 4️⃣ 𝑁𝑒𝑤 𝑎𝑣𝑒𝑛𝑢𝑒𝑠 𝑓𝑜𝑟 𝑡𝑟𝑒𝑎𝑡𝑚𝑒𝑛𝑡𝑠 💡 Understanding these mechanisms opens opportunities for combined therapies to make immunotherapy effective in more patients 🧬 Osteopontin emerges as a key protein to target in these new strategies Authors: Ana Henriques, Maria Salvany Celades, Paula Nieto, Sergio Palomo-Ponce, MARTA SEVILLANO, Xavier Hernando, Emily Middendorp Guerra, Montserrat Llanses Martinez, Elisabeth Marjolein Haak, Juan Nieto Sáchica, Ginevra Caratù, Domenica Marchese, Max R., Sébastien Tosi, Theresa Suckert, Jordi Badia-Ramentol, PhD, Adrià Caballé-Mestres, Carolina Sánchez Zarzalejo, Lidia Mateo, Daniele Tauriello, Antoni Riera, Elena Sancho, Camille Stephan Otto Attolini 🏳️🌈, Alejandro Prados, Holger Heyn, and Eduard Batlle. 📎 https://lnkd.in/dFVkNpBV #ColorectalCancer #Immunotherapy #SingleCellGenomics #CancerResearch #CNAG #IRBBarcelona #NatureGenetics

🐑 𝐃𝐢𝐝 𝐲𝐨𝐮 𝐤𝐧𝐨𝐰 𝐭𝐡𝐚𝐭 𝐠𝐞𝐧𝐨𝐦𝐢𝐜𝐬 𝐜𝐚𝐧 𝐡𝐞𝐥𝐩 𝐟𝐢𝐠𝐡𝐭 𝐢𝐧𝐟𝐞𝐜𝐭𝐢𝐨𝐧𝐬 𝐢𝐧 𝐚𝐧𝐢𝐦𝐚𝐥𝐬? Today we share a study linked to animal welfare and the sustainability of livestock farming. The parasitic mite Psoroptes ovis infests cattle and sheep, causing psoroptic mange, a painful skin disease that leads to intense itching, hair loss and open wounds. It’s a major threat to animal welfare and farm productivity. 𝘈 𝘣𝘳𝘦𝘢𝘬𝘵𝘩𝘳𝘰𝘶𝘨𝘩 𝘪𝘯 𝘶𝘯𝘥𝘦𝘳𝘴𝘵𝘢𝘯𝘥𝘪𝘯𝘨 𝘥𝘳𝘶𝘨 𝘳𝘦𝘴𝘪𝘴𝘵𝘢𝘯𝘤𝘦 A new international study published in PLOS Pathogens, with the collaboration of CNAG, has revealed how these mites develop resistance to treatments commonly used to control infections. Using the most complete genetic map of this parasite to date, created by CNAG, researchers led by SRUC, Universiteit Gent and the Moredun Research Institute found that resistant mites activate certain genes more strongly and in extra copies, allowing them to break down treatments and survive. 𝘉𝘦𝘩𝘪𝘯𝘥 𝘵𝘩𝘦 𝘴𝘤𝘪𝘦𝘯𝘤𝘦 This work was carried out by CNAG’s Genome Assembly and Annotation Team, with Tyler Alioto, Jèssica Gómez Garrido, @Francisco Cámara and Fernando Cruz, together with Marta Gut, Head of the Sequencing Unit, and Ivo Gut, CNAG Director. Their contribution was crucial to accurately interpret the genetic variation underlying resistance. 𝘛𝘰𝘸𝘢𝘳𝘥𝘴 𝘴𝘶𝘴𝘵𝘢𝘪𝘯𝘢𝘣𝘭𝘦 𝘢𝘯𝘪𝘮𝘢𝘭 𝘩𝘦𝘢𝘭𝘵𝘩 This discovery sheds light on the genetic mechanisms behind drug resistance, paving the way for more effective control strategies and more sustainable livestock management. 🔗 https://lnkd.in/eKMYpiGR #Genomics #AnimalHealth #Livestock #DrugResistance #CNAG #Research #GenomeMapping #PLOSPathogens #Sustainability

🚀 𝐍𝐞𝐰 𝐢𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐢𝐧𝐭𝐨 𝐭𝐡𝐞 𝐛𝐢𝐨𝐥𝐨𝐠𝐲 𝐨𝐟 𝐡𝐞𝐚𝐫𝐢𝐧𝐠 𝐥𝐨𝐬𝐬! 👂 A collaborative study led by researchers from the Universitat de Barcelona and Bellvitge Biomedical Research Institute - IDIBELL, with support from CNAG, has uncovered the genetic mechanisms behind the early stages of hearing loss. 🧬 At CNAG, our team contributed to the RNA sequencing and analysis, helping to decode the molecular signals that precede sensory damage. This work was led by Marta Gut, Head of the Sequencing Unit, together with Functional Genomics Team members Anna Esteve Codina and Beatriz Martín Mur. 1️⃣ 𝐴 𝑏𝑖𝑡 𝑜𝑓 𝑐𝑜𝑛𝑡𝑒𝑥𝑡 👉 Certain drugs and chemicals can harm the vestibular system and its hair cells, which have very limited capacity to regenerate. 👉 Prolonged exposure can result in permanent sensory loss. 2️⃣ 𝐾𝑒𝑦 𝑓𝑖𝑛𝑑𝑖𝑛𝑔𝑠 🔎 One of the earliest responses to damage is the downregulation of hair cell–specific genes. 🔎 Understanding these changes could help guide protective strategies and prevent long-term hearing impairment. 📎 https://lnkd.in/d8niAkFK #Genomics #HearingLoss #RNAseq #BiomedicalResearch #CNAG #IDIBELL #UniversitatdeBarcelona